Growing up during the communist era and witnessing the 1989 Revolution at the age of 12, Mureșan's work critically reflects on Romania's socio-political transformations and the broader implications of post-communist transitions. He often draws from historical, political, social, and cultural references—particularly in art, literature, and cinema—which he reinterprets within contemporary contexts. A particular interest of him is how culture is disseminated, the complex interplay between collective memory and present-day realities, and the dynamics between political authority, religious influence, and civil society.
The artist represented Romania at the 53rd Venice Biennale in 2009 and took part in the 17th Biennale of Sydney in 2010. In 2017 he participated in the main part of the exhibition of the 57th Venice Biennale and in 2024 he was curator for the Romanian Pavilion of the 60th Venice Biennale . His works have been showcased in many institutions worldwide such as the Centre Pompidou in Paris, the Witte de With in Rotterdam, and the Museum in New York.